CADASTER Workshop on the use of QSAR models in REACH


First Cadaster workshop was organized in Maribor, Slovenia, as a part of CMPTI conference (http://cmtpi-2011.si) and took place from September 1st to 2nd 2011. Workshop aims were to assist the risk assessors and national chemicals autho­rities, particular in Eastern European countries, with the use of the QSAR tools for the risks assessments in REACH.

The agenda was as follows:

Thursday, 1st September

Time Topic Speaker
13:30-14:00 General philosophy of Cadaster Dr. Willie Peijnenburg, RIVM, The Netherlands
14:10-14:40 Satisfying REACH requirements with OpenTox Dr. Barry Hardy, Douglas Connect
14:50-15:20 Legislative overview on the use of alternative methods in REACH Dr. Evelin Fabjan, ECHA, Finland
15:20-15:50 Coffee Break
15:50-16:20 Technical information on alternative methods Dr. Andrew Worth, JRC, Italy
16:30-17:00 Cadaster achievements
Exemplification of the integration of tools within REACH: the CADASTER project
Database on experimental parameters and (Q)SARs

Dr. Willie Peijnenburg, RIVM, The Netherlands

Dr. Mojca Kos Durjava, PHI, Slovenia

Friday, 2nd September

Time Topic Speaker
09:00-09:30 State of the art in QSAR modeling Dr. Alex Tropsha, University of North Carolina, USA
09:40-10:40 Cadaster achievements
Development and validation of QSAR models
Integration of QSARs with risk assessment
Dissemination of information in CADASTER project

Dr. Paola Gramatica, University of Insubria, Italy
Dr. Tomas Oberg, Linnaeus University, Sweden
Dr. Igor Tetko, HMGU, Germany
10:50-11:20 Coffee Break
11:20-13:00 Training lessons for on-line tools that can be used to estimate REACH end- points for chemical compounds and thus decrease the number of animal tests
Demonstration of tools developed in Cadaster
See tutorial here




Dr. Igor Tetko, HMGU, Germany
13:00-14:30 Lunch Break
14:30-16:00 Training lessons for on-line tools that can be used to estimate REACH end- points for chemical compounds and thus decrease the number of animal tests
OECD QSAR Toolbox and CADASTER




Dr. Emil Rorije, RIVM, The Netherlands
16:00-17:00 Panel Discussion Dr. Willie Peijnenburg, RIVM, The Netherlands

The feed-back of workshop participants will be very important for the customisation of the tools for the use by the regulatory agencies.

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